XVI NIBIT MEETING PRELIMINARY PROGRAM - Milan, October 11-13, 2018 - Professional congress organiser
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PRELIMINARY PROGRAM XVI NIBIT MEETING Milan, October 11-13, 2018 San Raffaele Congress Centre, Milan Under the auspices of
XV I N I B I T Scientific Committee Alberto Amadori, Padova Massimo Di Nicola, Milano Matteo Bellone, Milano Pier Francesco Ferrucci, Milano Marco Bregni, Busto Arsizio - VA Enrico Proietti, Roma Luana Calabrò, Siena Vincenzo Russo, Milano Mario Paolo Colombo, Milano Faculty Alberto Amadori Massimo Di Nicola Federica Moschella Università degli Studi di Padova, IRCCS Istituto Nazionale Istituto Superiore di Sanità, Padova (Italy) dei Tumori, Milano (Italy) Roma (Italy) Sebastian Amigorena Gianpietro Dotti Antonio Moschetta Université Paris Descartes, UNC School of Medicine, Università degli Studi di Bari Paris (France) Chapel Hill | NC (USA) Aldo Moro, Bari (Italy) Matteo Bellone Soldano Ferrone Massimiliano Pagani IRCCS Ospedale San Raffaele, Massachusetts General Hospital, Università degli Studi di Milano, Milano (Italy) Boston | MA (USA) Milano (Italy) Pier Francesco Ferrucci Anna Pastò Marco Bregni Istituto Europeo di Oncologia Azienda Ospedaliera Ospedale Istituto Oncologico Veneto IOV, IEO, Milano (IT) Padova (Italy) di Circolo, Busto Arsizio | VA (Italy) Wolf Herman Fridman Giuseppe Procopio Université Paris Descartes, Andrea Botticelli IRCCS Istituto Nazionale Paris (France) Ospedale Sant’Andrea, dei Tumori, Milano (Italy) Vanesa Gregorc Roma (Italy) IRCCS Ospedale San Raffaele, Enrico Proietti Vincenzo Bronte Milano (Italy) Istituto Superiore di Sanità, Università degli Studi di Verona, Roma (Italy) Niels Halama Verona (Italy) Universitätsklinikums Heidelberg, Maria Pia Protti Luana Calabrò Heidelberg (Germany) IRCCS Ospedale San Raffaele, Milano (Italy) Azienda Ospedaliera Alexandre Harari Universitaria Senese, Siena (Italy) CHUV centre hospitalier Paola Queirolo Arianna Calcinotto universitaire vaudois, IRCCS Ospedale San Martino, Institute of Oncology Research Lausanne (Switzerland) Genova (Italy) IOR, Bellinzona (Switzerland) Guido Kroemer Rahul Roychoudhuri Université Paris Descartes, Babraham Institute, Cambridge (UK) Monica Casucci Paris (France) IRCCS Ospedale San Raffaele, Marco Ruella Milano (Italy) Franco Locatelli Penn Medicine Hospital of the IRCCS Ospedale Pediatrico University of Pennsylvania, Mario Paolo Colombo Bambin Gesù, Roma (Italy) IRCCS Istituto Nazionale Pennsylvania | PA (USA) dei Tumori, Milano (Italy) Enrico Lugli Dario Sangiolo Istituto Clinico Humanitas, Università degli Studi di Torino, Mark S. Cragg Rozzano | MI (Italy) Torino (Italy) University of Southampton, Chiara Magnani Southampton (UK) Università degli Studi di Milano Antonio Sica Michele De Palma Bicocca, Milano (Italy) Istituto Clinico Humanitas, École Polytechnique Fédérale Rozzano | MI (Italy) Susanna Mandruzzato de Lausanne, Lausanne Università degli Studi di Padova, Sjoerd van der Burg (Switzerland) Padova (Italy) Leiden University Medical Centre, Leiden (The Netherlands) Anna Maria Di Giacomo Massimo Massaia Azienda Ospedaliera Azienda Ospedaliera Citta’ Laurence Zitvogel Universitaria Senese, della Salute e della Scienza, Université Paris-Sud, Paris Siena (Italy) Torino (Italy) (France) 2
MEETING SCIENTIFIC THURSDAY - OCTOBER 11 12.30 Light Lunch and registration 14.00 Welcome addresses Session 1 - Tumor Microenvironment I Chairs: Massimo Di Nicola, Maria Pia Protti 14.15 Immune and Tumor cell cooperations in shaping the tumor microenvironment Wolf Herman Fridman (Paris, France) 14.40 In silico modeling of immunotherapy and stroma-targeting therapies in human colorectal cancer Niels Halama (Heidelberg, Germany) 15.05 Deep interrogation and profiling of tumor-infiltrating T lymphocytes Alexandre Harari (Lausanne, Switzerland) 15.30 2 Selected Abstracts 16.00 Coffee Break Session 2 - Tumor Microenvironment II Chairs: Alberto Amadori, Arianna Calcinotto 16.20 Myelopoiesis in cancer: “Flipping” over monocytes into immune regulatory cells Vincenzo Bronte (Verona, Italy) 16.45 Single cell transcriptome analysis of human tumor-infiltrating lymphocytes Massimiliano Pagani (Milano, Italy) 17.10 Chemotherapy, innate immunity and tumor metastasis Michele De Palma (Lausanne, Switzerland) 17.35 2 Selected Abstracts 18.30 General Assembly of the NIBIT 20.00 Welcome Wine & Cheese 3
XV I N I B I T SCIENTIFIC PROGRAM FRIDAY, OCTOBER 12 Session 3 - Adoptive Immunotherapy Chairs: Marco Bregni, Monica Casucci 09.00 CAR-T cells in pediatric hematologic malignancies Franco Locatelli (Roma, Italy) 09.25 CAR-T cells in adult hematologic malignancies Marco Ruella (Philadelphia, USA) 09.50 CAR-T cells in adult hematologic malignancies Chiara Magnani (Milano, Italy) 10.15 CAR-T cells in brain tumor Gianpietro Dotti (Chapel Hill, USA) 10.40 1 Selected Abstract 10.55 Coffee break Session 4 - Microbiota and Metabolism Chairs: Matteo Bellone, Anna Pastò 11.15 The intrinsic role of cholesterol metabolism and nuclear receptors in tumorigenesis Antonio Moschetta (Bari, Italy) 11.40 Gut oncomicrobiome fingerprints in cancer Laurence Zitvogel (Paris, France) 12.05 Metabolic reprogramming and myeloid cell heterogeneity in cancer Antonio Sica (Milano, Italy) 12.30 3 Selected Abstracts 13.15 Lunch Session 5 - Tumor and T cells Interactions Chairs: Mario Paolo Colombo, Federica Moschella 14.15 Neoantigen landscape dynamics during human melanoma-T cell interactions Sjoerd van der Burg (Leiden, The Netherlands) 14.40 Understanding agonism: rules and exceptions for TNF receptors Mark S Cragg (Southampton, UK) 15.05 Tumor-intrinsic PD1 expression: biological role and potential therapeutic relevance Dario Sangiolo (Torino, Italy) 15.30 3 Selected Abstracts 4
MEETING 16.00 Coffee break 16.30 Soldano Ferrone (Boston, USA) introduces the Keynote Lecture Keynote Lecture: Guido Kroemer (Paris, France) Therapeutic manipulation of oncometabolism and immunometabolism 20.00 Social Dinner at Terrazza Aperol SATURDAY, OCTOBER 13 Session 6 - Biology of T Cells and Innate Lymphoid Cells in Cancer Chairs: Susanna Mandruzzato, Enrico Proietti 09.00 Control of signal-driven transcriptional programmes in T cells Rahul Roychoudhuri (Cambridge, UK) 09.25 Anti-tumor T cell immunity at single cell resolution Enrico Lugli (Milano, Italy) 09.50 Epigenetic control of anti-tumor immune responses Sebastian Amigorena (Paris, France) 10.15 Vγ9Vδ2 T cells activation by phosphoantigens released by antigen-presenting cells Massimo Massaia (Torino, Italy) 10.30 3 Selected Abstracts 11.00 Coffee break Session 7 - Clinical and Research Highlights Around NIBIT Chairs: Luana Calabrò, Pier Francesco Ferrucci 11.20 Tyrosine Kinase Inhibitors and antitumor immune responses Andrea Botticelli (Roma, Italy) 11.40 Immunotherapy in the treatment of urogenital cancer Giuseppe Procopio (Milano, Italy) 12.00 Targeted therapies in the treatment of metastatic melanoma Paola Queirolo (Genova, Italy) 12.20 Immunotherapy in the treatment of NSCLC Vanesa Gregorc (Milano, Italy) 12.40 The NIBIT Foundation Clinical Trials Anna Maria Di Giacomo (Siena, Italy) 13.00 NIBIT Awards Nominations 13.30 Lunch 14.30 Adjourn 5
XV I N I B I T Call for abstract All those interested in taking part may submit an abstract in English, following the guidelines included in the template. The Scientific Committee will analyze all paper and confirm the acceptance to each submitter. Papers could be selected as oral presentation or poster presentation. DEADLINES FOR ABSTRACT SUBMISSION AND REGISTRATIONS Abstracts should be submitted to the e-mail address alice.trovato@achelois.eu by September 17, 2018. Abstracts submitted by fax will not be accepted. Abstracts will be reviewed by the Scientific Committee and acceptance will be confirmed, together with all details for presenting your work, by September 30, 2018. The presenting author of an accepted project must register by October 5, 2018. Registration is mandatory for presenting the poster. COMPETITION AND PRIZE Applicants
MEETING Abstract form to be sent by e-mail to the Organising Secretariat (alice.trovato@achelois.eu) by September 17th, 2018. PRESENTING AUTHOR (Name, Surname, Institution, Institution Address, Department, Mobile phone, e-mail) OTHER AUTHORS ABSTRACT TITLE ABSTRACT TEXT (max 2500 characters – including spaces) Background Methods Results Conclusions In accordance with General Data Protection Regulation UE 2016/679 we declare that the holder of data processing is Acheloís Srl. I authorize Acheloís Srl to handle my personal data for purposes strictly connected to the present and future registrations. Acheloís Srl declares that this data will not be divulged or delivered to third parties, that are not strictly involved in the event management. Signature 7
Acknowledgments Congress Venue San Raffaele Congress Centre Via Olgettina, 58 20132 Milan - Italy Useful Information Registration http://achelois.onlinecongress.it/NIBITMeeting2018 Official website http://www.nibit.org/meeting/index.php Organising Secretariat Acheloís Professional Congress Organiser Via Olgettina 58 - Milan, IT Phone: +39 02 2643 6227 e-mail: linda.isella@achelois.eu ACHELOÍS - Professional Congress Organiser
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