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CAPITOLO V
PRESENTAZIONE DELL’EDIZIONE ITALIANA
Il Goldman-Cecil Medicina Interna torna nelle librerie italiane! Dopo 16 anni di professionale, di assicurare una valutazione dell’insieme e non delle singole parti
assenza, lo studente di medicina così come lo specializzando o lo specialista – non costituenti l’insieme. Da ciò emerge con chiarezza il concetto della complessità,
solo in Medicina Interna – avranno nuovamente a disposizione questo importan- il cui approccio sistematico non vuole dire mera comprensione olistica dell’in-
te trattato che continua a essere uno strumento irrinunciabile nella formazione dividuo malato. Il fenotipo o fenoma complesso, lungi dall’essere una semplice
pre- e post-laurea. sommatoria delle condizioni morbose che lo compongono, rappresenta un’en-
Punti di forza restano l’impostazione fisiopatologica, cardine insostituibile tità fenomenica in cui le singole parti interagiscono fra loro in maniera dinamica
nel ragionamento clinico, e l’ampio spazio dedicato all’inquadramento clinico di con i determinanti non biologici, al fine di realizzare un unico sistema funzionale.
ciascuna condizione morbosa; elementi questi molto vicini alla cultura medica Non potendo prescindere dalla realtà sanitaria ed economica in cui ci troviamo,
italiana non sempre adeguatamente valorizzati in altre opere simili. Altro elemen- il suddetto approccio si propone di individuare fra tutti i determinanti e le loro
to di particolare valore dal punto di vista didattico è rappresentato dall’ampia di- connessioni quelli che hanno un ruolo chiave nell’influenzare lo stato di salute
sponibilità di filmati e altro materiale iconografico presente sul sito web dedicato. dell’individuo, sia nell’immediato sia nel futuro, in modo da identificare le pri ori-
L’unitarietà della trattazione dei singoli capitoli è un ulteriore punto di forza tà e pianificare una strategia terapeutica e assistenziale unitaria. Una capacità que-
del Cecil perché risponde concretamente a un’esigenza forte e qualificante del sta che consente una visione equilibrata che consenta anche un uso oculato dei
medico che, dopo anni di medicina specialistica, basata fondamentalmente sulla farmaci, la così detta riconciliazione farmacologica, estremamente importante per
patologia d’organo, ha recuperato il vecchio, ma mai desueto, concetto di gestione evitare i possibili rischi di reazioni indesiderate, soprattutto nei pazienti anziani e
olistica del paziente, guidando il lettore nella costruzione del ragionamento clini- politrattati per la loro multimorbilità.
co, strumento irrinunciabile per il corretto inquadramento del paziente. È evidente, quindi, che è necessario definire nuovi percorsi formativi e model-
L’epidemiologia attuale è caratterizzata dalla cronicità e multimorbilità, condi- li clinico-gestionali che sappiano adeguare l’assistenza socio-sanitaria alla nuova
zioni queste che ridimensionano fortemente la visione limitata dello specialista realtà epidemiologica, concentrando l’attenzione: sullo stato di salute e benessere
d’organo, anche se il suo contributo resta importante e insostituibile in ambiti complessivo della persona, non sulla singola malattia; sull’integrazione fra ospe-
specifici. Tali evidenze, quindi, richiedono il recupero della centralità del paziente dale e medicina del territorio; sull’appropriatezza e sulla sostenibile gestione delle
nella sua indissolubile unitarietà di corpo e di spirito, di soma e psiche; processo risorse. Ecco, quindi, la necessità di un professionista – l’Internista – che sappia
fondamentale dal punto di vista clinico ma che prevede un profondo cambiamen- governare questa transizione verso i nuovi modelli clinico-assistenziali che, appa-
to culturale sia nella classe medica sia nella popolazione. rentemente, sembrano essere in contrapposizione con la medicina personalizzata
Ovviamente, questo cambiamento culturale presuppone, altresì, l’adozione o di precisione. Un processo formativo che inizia negli anni pre-laurea per conti-
di nuovi modelli organizzativi e gestionali perché il Sistema Sanitario Nazionale nuare, poi, nel periodo post-laurea e affinarsi indefinitamente nella pratica clini-
stesso, oltre che efficiente ed efficace, sia economicamente sostenibile ed etica- ca quotidiana. Un contributo concreto a tale percorso può essere assicurato dal
mente equo. Queste ultime problematiche sono generate dalla cronicità di cui Goldman-Cecil Medicina Interna di cui la Società Italiana di Medicina Interna ha
sopra, dal progressivo allungamento della vita e dalle nuove terapie innovative voluto curare la traduzione della 25a edizione americana. A tale attività editoriale,
che, a fronte della loro innegabile efficacia, sono gravate da costi elevati. Probabil- non certo facile, hanno contribuito esperti riconosciuti e apprezzati nella Comu-
mente, il chronic care model, teorizzato da oltre vent’anni, potrebbe rappresentare nità internistica nazionale e internazionale ai quali va il mio apprezzamento e rin-
lo strumento più idoneo per gestire la crescente complessità biologica e organiz- graziamento particolare. Grazie a loro, è ora disponibile anche la 25aedizione ita-
zativa del paziente con cronicità e multimorbilità. Un modello organizzativo che liana del Goldman-Cecil Medicina Interna a cui auguro lo stesso successo editoriale
prevede anche l’empowerment del paziente stesso, non solo dal punto di vista dia- che ha avuto negli USA e in tutti i Paesi in cui si è proceduto alla sua traduzione.
gnostico-terapeutico, ma soprattutto dal punto di vista preventivo.
È in questo nuovo scenario che emerge l’importanza della figura dello Spe- FRANCESCO PERTICONE
cialista in Medicina Interna che è in grado, per la sua impostazione culturale e Presidente Società Italiana di Medicina Interna
B
0001-v01-PrefazioneITA-V-VI.indd 5 15/05/17 17:12CAPITOLO VII
PREFAZIONE DELL’EDIZIONE AMERICANA
Sono trascorsi novant’anni dalla pubblicazione della prima edizione del Cecil Tex- mott, James Wyngaarden, Lloyd H. Smith, Jr., Fred Plum, J. Claude Bennett, e
tbook of Medicine e in questo lasso di tempo le nostre conoscenze sulla medicina Dennis Ausiello. Mentre diamo il nostro benvenuto ai nuovi co-editor – Mary K.
interna sono quasi completamente cambiate. Il progresso delle scienze mediche Crow, James H. Doroshow, e Allen M. Spiegel – esprimiamo anche la nostra gra-
sta oggi evolvendo a una velocità sempre maggiore, in un contesto di modifiche titudine a William P. Arend, James O. Armitage, David R. Clemmons, e agli altri
strutturali della pratica clinica e di nuove modalità di erogare l’assistenza sanitaria delle edizioni precedenti, sulle cui fondamenta abbiamo costruito. I co-editor che
a livello individuale, sociale e globale. Questo libro e i sussidi elettronici a esso ancora collaborano – Jeffrey M. Drazen, Robert C. Griggs, Donald W. Landry,
associati raccolgono le più recenti conoscenze mediche in formati diversi, così Wendy Levinson, Anil K. Rustgi, e W. Michael Scheld – continuano a dare il loro
da attrarre e soddisfare tanto lo studente quanto il professionista esperto, indi- contributo essenziale alla selezione degli autori e alla revisione e approvazione
pendentemente dalle loro preferenze su come accedere a queste informazioni in di tutti i manoscritti. Solo agli editor va tuttavia la piena responsabilità del libro e
rapida evoluzione. dell’integrazione tra i vari capitoli.
Peraltro, anche se i suoi contenuti specifici sono cambiati, il Cecil è rimasto fedele È tradizione del Cecil che tutti i capitoli siano scritti da esperti riconosciuti nei
alla tradizione d’essere un testo completo di medicina, che spiega con cura il perché rispettivi campi. Siamo anche molto grati per l’assistenza editoriale fornitaci a
(la fisiopatologia di base di una malattia) e il come (oggi basato sulle prove d’efficacia New York da Maribel Lim e Silva Sergenian. Costoro e gli altri nostri collaborato-
derivanti dai trial controllati randomizzati e dalle metanalisi). La descrizione dei ri hanno dimostrato una dedizione e un’equanimità straordinarie nell’interagire
quadri fisiologici e fisiopatologici comprende i più recenti progressi della genetica, con autori ed editor per la gestione del flusso continuo di manoscritti, illustra-
presentati in un formato di facile comprensione, utile anche ai non esperti. La medi- zioni e autorizzazioni. Ringraziamo inoltre Cassondra Andreychik, Ved Bhushan
cina è entrata in un’era in cui l’acuzie della malattia e la scarsità del tempo da dedica- Arya, Cameron Harrison, Karen Krok, Robert J. Mentz, Gaétane Nocturne, Pa-
re alla valutazione del paziente hanno ridotto la possibilità del medico di soddisfare trice Savard, Senthil Senniappan, Tejpratap Tiwari, e Sangeetha Venkatarajan, che
la propria curiosità intellettuale. Ne deriva che si fa spesso confusione tra la sem- hanno contribuito alla stesura di vari capitoli; piangiamo la scomparsa di Mor-
plice acquisizione di informazioni, indubbiamente facile di questi tempi, e la vera ton N. Swartz, MD, co-autore del capitolo “Meningiti: batteriche, virali e da altre
conoscenza. Abbiamo cercato di affrontare questo dilemma con un libro che non cause” e di Donald E. Low, MD, autore del capitolo “Infezioni streptococciche
solo fornisca informazioni, ma stimoli anche nuove domande e faccia intravedere non pneumococciche e febbre reumatica”. In Elsevier, siamo soprattutto grati a
le strade future verso le nuove conoscenze. Nel testo, le evidenze di grado A sono Kate Dimock e a Maureen Iannuzzi, e ringraziamo anche Maria Holman, Gabriela
espressamente evidenziate, col relativo riferimento bibliografico al termine di ogni Benner, Cindy Thoms, Anne Altepeter, Linda McKinley, Paula Catalano, e Kristin
capitolo (Bibliografia specialistica). In aggiunta alle informazioni fornite dal volume Koehler, che hanno svolto un ruolo cruciale nel processo di programmazione e
cartaceo, il sito web del Cecil rende disponibili ulteriori contenuti e funzionalità. In produzione, sotto la guida di Mary Gatsch. Molte delle fotografie dei quadri cli-
molti casi, dal sito si può accedere direttamente alla versione in extenso degli articoli nici sono state fornite da Charles D. Forbes e William F. Jackson, autori del Color
citati in bibliografia nei vari capitoli. Le sezioni dedicate a ciascun apparato iniziano Atlas e Text of Clinical Medicine, terza edizione, pubblicata nel 2003 da Elsevier
con un capitolo che riassume l’approccio al paziente, con i sintomi, i segni e le alte- Science Ltd. Li ringraziamo per averci cortesemente permesso di inserire le loro
razioni di laboratorio tipicamente associati all’alterato funzionamento di quell’appa- immagini nel nostro libro. Nella nostra vita abbiamo incontrato medici eccezio-
rato. Come indicato nella Tabella E1-1, il testo offre in modo specifico informazioni nali e desideriamo riconoscere il ruolo di guida e sostegno di alcuni di coloro che
chiare e concise su come il medico dovrebbe affrontare più di 100 comuni sintomi, bene rappresentano questa situazione – Eugene Braunwald, Lloyd H. Smith, Jr.,
segni e alterazioni di laboratorio, impiegando di solito un diagramma di flusso, una Frank Gardner, e William Castle. Infine, vogliamo ringraziare la famiglia Goldman
tabella o entrambi per maggiore chiarezza. In questo modo, il Cecil rimane un te- – Jill, Jeff, Abigail, Mira, Samuel, Daniel, Robyn, Tobin, e Dashel – e la famiglia
sto completo ed esauriente, in grado di guidare la diagnosi e la terapia non solo nei Schafer – Pauline, Eric, Melissa, Nathaniel, Pam, John, Evan, Samantha, Kate, e
pazienti con una malattia sospetta o nota, ma anche in quelli con alterazioni non Sean – per aver compreso quanto tempo e attenzione fossero necessari per revi-
diagnosticate che richiedono quindi una valutazione iniziale. sionare un libro che vuole continuare la tradizione dei nostri predecessori e sod-
Come ciascuna edizione vede la partecipazione di nuovi autori, così anche ci disfare le esigenze dei medici contemporanei.
ricorda la gratitudine verso gli editor e gli autori delle edizioni precedenti. I pre-
cedenti editor del Cecil comprendono un piccolo ma assai qualificato gruppo di LEE GOLDMAN, MD
personalità della medicina americana: Russell Cecil, Paul Beeson, Walsh McDer- ANDREW I. SCHAFER, MD
B
0002-v01-PrefazioneUSA-VII-VIII.indd 7 15/05/17 12:49AUTORI XV
AUTORI
Charles S. Abrams, MD Larry J. Anderson, MD
Professor of Medicine, Pathology, and Laboratory Medicine, University of Professor, Division of Infectious Disease, Department of Pediatrics, Emory
Pennsylvania School of Medicine; Director, PENN-Chop Blood Center University School of Medicine and Children’s Healthcare of Atlanta,
for Patient Care & Discovery, Hospital of the University of Pennsylvania, Atlanta, Georgia
Philadelphia, Pennsylvania Coronaviruses
Thrombocytopenia
Aśok C. Antony, MD
Frank J. Accurso, MD Chancellor’s Professor of Medicine, Indiana University School of Medicine;
Professor of Pediatrics, University of Colorado School of Medicine; Attending Physician, Indiana University Health Affiliated Hospitals and
Attending Physician, Children’s Hospital Colorado, Aurora, Colorado Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis,
Cystic Fibrosis Indiana
Megaloblastic Anemias
Ronald S. Adler, MD, PhD
Professor of Radiology, New York University School of Medicine; Gerald B. Appel, MD
Department of Radiology, NYU Langone Medical Center, New York, Professor of Medicine, Division of Nephrology, Department of Medicine,
New York Columbia University College of Physicians and Surgeons, New York,
Imaging Studies in the Rheumatic Diseases New York
Glomerular Disorders and Nephrotic Syndromes
Cem Akin, MD, PhD
Associate Professor, Harvard Medical School; Attending Physician, Frederick R. Appelbaum, MD
Director, Mastocytosis Center, Brigham and Women’s Hospital, Executive Vice President and Deputy Director, Fred Hutchinson Cancer
Department of Medicine, Division of Rheumatology, Immunology, and Research Center; President, Seattle Cancer Care Alliance; Professor,
Allergy, Boston, Massachusetts Division of Medical Oncology, University of Washington School of
Mastocytosis Medicine, Seattle Washington
The Acute Leukemias
Allen J. Aksamit, Jr., MD
Professor of Neurology, Mayo Clinic College of Medicine, Consultant in Suneel S. Apte, MBBS, DPhil
Neurology, Mayo Clinic, Rochester, Minnesota Staff, Cleveland Clinic Lerner College of Medicine at Case Western
Acute Viral Encephalitis Reserve University, Cleveland, Ohio
Connective Tissue Structure and Function
Qais Al-Awqati, MB ChB
Robert F. Loeb Professor of Medicine, Jay I. Meltzer Professor of James O. Armitage, MD
Nephrology and Hypertension, Professor of Physiology and Cellular The Joe Shapiro Professor of Internal Medicine, University of Nebraska
Biophysics, Division of Nephrology, Columbia University, College of Medical Center, Omaha, Nebraska
Physicians and Surgeons, New York, New York Approach to the Patient with Lymphadenopathy and Splenomegaly;
Structure and Function of the Kidneys Non-Hodgkin Lymphomas
Ban Mishu Allos, MD M. Amin Arnaout, MD
Associate Professor of Medicine, Division of Infectious Diseases, Associate Professor of Medicine, Departments of Medicine and Developmental and
Professor, Preventive Medicine, Vanderbilt University School of Regenerative Biology, Harvard Medical School; Physician and Chief
Medicine, Nashville, Tennessee Emeritus, Division of Nephrology, Massachusetts General Hospital,
Campylobacter Infections Boston, Massachusetts
Cystic Kidney Diseases
David Altshuler, MD, PhD
Professor of Genetics and of Medicine, Harvard Medical School, Robert M. Arnold, MD
Massachusetts General Hospital; Professor of Biology (Adjunct), Leo H. Criep Professor of Clinical Care, Chief, Section of Palliative Care
Massachusetts Institute of Technology, Boston and Cambridge, and Medical Ethics, University of Pittsburgh; Medical Director, UPMC
Massachusetts Palliative and Supportive Care Institute, Pittsburgh, Pennsylvania
The Inherited Basis of Common Diseases Care of Dying Patients and Their Families
Michael Aminoff, MD, DSc David Atkins, MD, MPH
Professor, Department of Neurology, University of California San Director, Health Services Research and Development, Veterans Health
Francisco, San Francisco, California Administration, Washington, D.C.
Approach to the Patient with Neurologic Disease The Periodic Health Examination
Jeffrey L. Anderson, MD John P. Atkinson, MD
Professor of Internal Medicine, University of Utah School of Medicine; Chief, Division of Rheumatology, Internal Medicine, Washington
Vice-Chair for Research, Department of Internal Medicine, Associate University School of Medicine in St. Louis, St. Louis, Missouri
Chief of Cardiology and Director of Cardiovascular Research, Complement System in Disease
Intermountain Medical Center, Intermountain Healthcare, Salt Lake City,
Utah
ST Segment Elevation Acute Myocardial Infarction and Complications of Myo-
cardial Infarction
0008-v01-Co-AutoriUSA-XV-XXXVI.indd 15 24/05/17 14:43XVI AUTORI
Bruce R. Bacon, MD Stephen G. Baum, MD
Endowed Chair in Gastroenterology, Professor of Internal Medicine, Chairman of Medicine, Mount Sinai Beth Israel Hospital; Professor of
Co-Director, Saint Louis University Liver Center; Director, Saint Louis Medicine and of Microbiology and Immunology, Albert Einstein College
University Abdominal Transplant Center, Saint Louis University School of Medicine, New York, New York
of Medicine, St. Louis, Missouri Mycoplasma Infections
Iron Overload (Hemochromatosis)
Daniel G. Bausch, MD, MPH&TM
Larry M. Baddour, MD Associate Professor, Department of Tropical Medicine, Tulane University
Professor of Medicine, Chair, Division of Infectious Diseases, Mayo Clinic, Health Sciences Center, New Orleans, Louisiana
Rochester, Minnesota Viral Hemorrhagic Fevers
Infective Endocarditis
Arnold S. Bayer, MD
Grover C. Bagby, MD Professor of Medicine, David Geffen School of Medicine at University of
Professor of Medicine and Molecular and Medical Genetics, Knight Cancer California Los Angeles; LA Biomedical Research Institute; Vice Chair
Institute at Oregon Health and Science University and Portland VA for Academic Affairs, Department of Medicine, Harbor-UCLA Medical
Medical Center, Portland, Oregon Center, Los Angeles, California
Aplastic Anemia and Related Bone Marrow Failure States Infective Endocarditis
Barbara J. Bain, MBBS Hasan Bazari, MD
Professor in Diagnostic Haematology, Imperial College London; Honorary Associate Professor of Medicine, Harvard Medical School, Department of
Consultant Haematologist, St. Mary’s Hospital, London, United Medicine, Clinical Director, Nephrology, Program Director, Internal
Kingdom Medicine Residency Program, Massachusetts General Hospital, Boston,
The Peripheral Blood Smear Massachusetts
Approach to the Patient with Renal Disease
Dean F. Bajorin, MD
Attending Physician and Member, Medicine, Memorial Hospital, Memorial John H. Beigel, MD
Sloan Kettering Cancer Center; Professor of Medicine, Weill Cornell National Institute of Allergy and Infectious Diseases, National Institutes of
Medical College, New York, New York Health, Bethesda, Maryland
Tumors of the Kidney, Bladder, Ureters, and Renal Pelvis Antiviral Therapy (Non-HIV)
Robert W. Baloh, MD George A. Beller, MD
Professor of Neurology, University of California Los Angeles School of Professor of Medicine, University of Virginia Health System,
Medicine, Los Angeles, California Charlottesville, Virginia
Neuro-Ophthalmology; Smell and Taste; Hearing and Equilibrium Noninvasive Cardiac Imaging
Jonathan Barasch, MD, PhD Robert M. Bennett, MD
Professor of Medicine and Pathology and Cell Biology, Department of Professor of Medicine, Oregon Health and Science University, Portland,
Medicine, Division of Nephrology, Columbia University College of Oregon
Physicians & Surgeons, New York, New York Fibromyalgia, Chronic Fatigue Syndrome, and Myofascial Pain
Structure and Function of the Kidneys
Joseph R. Berger, MD
Richard L. Barbano, MD, PhD Professor of Neurology, Chief of the Multiple Sclerosis Division,
Professor of Neurology, University of Rochester, Rochester, New York Department of Neurology, Perelman School of Medicine, University of
Mechanical and Other Lesions of the Spine, Nerve Roots, and Spinal Cord Pennsylvania, Philadelphia, Pennsylvania
Cytomegalovirus, Epstein-Barr Virus, and Slow Virus Infections of the Central
Elizabeth Barrett-Connor, MD Nervous System; Neurologic Complications of Human Immunodeficiency Virus
Professor of Community and Family Medicine, University of California San Infection; Brain Abscess and Parameningeal Infections
Diego, San Diego, California
Menopause Paul D. Berk, MD
Professor of Medicine, Department of Medicine, Columbia University
John R. Bartholomew, MD College of Physicians and Surgeons, New York, New York
Section Head, Vascular Medicine, Cardiovascular Medicine, Cleveland Approach to the Patient with Jaundice or Abnormal Liver Tests
Clinic, Professor of Medicine, Cleveland Clinic Lerner College of
Medicine of Case Western Reserve University, Cleveland, Ohio Nancy Berliner, MD
Other Peripheral Arterial Diseases Professor of Medicine, Harvard Medical School; Chief, Division of
Hematology, Brigham and Women’s Hospital, Boston, Massachusetts
Mary Barton, MD, MPP Leukocytosis and Leukopenia
Vice President, Performance Measurement, National Committee for
Quality Assurance, Washington, D.C. James L. Bernat, MD
The Periodic Health Examination Louis and Ruth Frank Professor of Neuroscience, Professor of Neurology
and Medicine, Geisel School of Medicine at Dartmouth, Hanover, New
Robert C. Basner, MD Hampshire; Department of Neurology, Dartmouth-Hitchcock Medical
Professor of Medicine, Columbia University Medical Center; Director, Center, Lebanon, New Hampshire
Columbia University Cardiopulmonary Sleep and Ventilatory Disorders Coma, Vegetative State, and Brain Death
Center, Columbia University College of Physicians and Surgeons, New
York, New York Philip J. Bierman, MD
Obstructive Sleep Apnea Professor, Department of Internal Medicine, University of Nebraska
Medical Center, Omaha, Nebraska
Approach to the Patient with Lymphadenopathy and Splenomegaly;
Non-Hodgkin Lymphomas
0008-v01-Co-AutoriUSA-XV-XXXVI.indd 16 24/05/17 14:43AUTORI XVII
Michael R. Bishop, MD William E. Boden, MD
Professor of Medicine, Director, Hematopoietic Cellular Therapy Program, Professor of Medicine, Albany Medical College; Chief of Medicine, Albany
Section of Hematology and Oncology, Department of Medicine, Stratton VA Medical Center; Vice-Chairman, Department of Medicine,
University of Chicago, Chicago, Illinois Albany Medical Center, Albany, New York
Hematopoietic Stem Cell Transplantation Angina Pectoris and Stable Ischemic Heart Disease
Bruce R. Bistrian, MD, PhD, MPH Jean Bolognia, MD
Professor of Medicine, Beth Israel Deaconess Medical Center; Professor of Professor of Dermatology, Yale Medical School; Attending Physician,
Medicine, Harvard Medical School, Boston, Massachusetts Yale-New Haven Hospital, New Haven, Connecticut
Nutritional Assessment Infections, Hyperpigmentation and Hypopigmentation, Regional Dermatology,
and Distinctive Lesions in Black Skin
Joseph J. Biundo, MD
Clinical Professor of Medicine, Tulane Medical Center, New Orleans, Robert A. Bonomo, MD
Louisiana Chief, Medical Service, Louis Stokes Cleveland VA Medical Center;
Bursitis, Tendinitis, and Other Periarticular Disorders and Sports Medicine Professor of Medicine, Pharmacology, Biochemistry, Molecular Biology,
and Microbiology, Case Western Reserve University School of Medicine,
Adrian R. Black, PhD Cleveland, Ohio
Assistant Professor, Director of Tissue Sciences for the Eppley Institute, Diseases Caused by Acinetobacter and Stenotrophomonas Species
The Eppley Institute for Research in Cancer and Allied Diseases,
University of Nebraska Medical Center, Omaha, Nebraska Larry Borish, MD
Cancer Biology and Genetics Professor of Medicine, Allergy, and Clinical Immunology, University of
Virginia Health System, Charlottesville, Virgina
Charles D. Blanke, MD Allergic Rhinitis and Chronic Sinusitis
Professor of Medicine, Oregon Health and Science University, Portland,
Oregon Patrick J. Bosque, MD
Neoplasms of the Small and Large Intestine Associate Professor of Neurology, University of Colorado Denver School of
Medicine; Neurologist, Denver Health Medical Center, Denver,
Joel N. Blankson, MD, PhD Colorado
Associate Professor, Johns Hopkins University School of Medicine, Prion Diseases
Baltimore, Maryland
Immunopathogenesis of Human Immunodeficiency Virus Infection David J. Brenner, PhD, DSc
Higgins Professor of Radiation Biophysics, Center for Radiological
Martin J. Blaser, MD Research, Columbia University Medical Center, New York, New York
Muriel and George Singer Professor of Medicine, Professor of Radiation Injury
Microbiology, Director, Human Microbiome Program, New York
University Langone Medical Center, New York, New York Itzhak Brook, MD, MSc
Acid Peptic Disease; Human Microbiome Professor of Pediatrics and Medicine, Georgetown University, Georgetown
University Medical Center, Washington, D.C.
William A. Blattner, MD Diseases Caused by Non–Spore-Forming Anaerobic Bacteria; Actinomycosis
Professor and Associate Director, Institute of Human Virology, School of
Medicine, University of Maryland; Professor of Medicine, School of Enrico Brunetti, MD
Medicine, University of Maryland; Professor and Head, Division of Assistant Professor of Infectious Diseases, University of Pavia; Attending
Cancer Epidemiology, Department of Epidemiology and Public Health, Physician, Division of Infectious and Tropical Diseases, IRCCS San
School of Medicine, University of Maryland, Baltimore, Maryland Matteo Hospital Foundation; Co-Director, WHO Collaborating Centre
Retroviruses Other Than Human Immunodeficiency Virus for Clinical Management of Cystic Echinococcosis, Pavia, Italy
Cestodes
Thomas P. Bleck, MD
Professor of Neurological Sciences, Neurosurgery, Internal Medicine, and David M. Buchner, MD, MPH
Anesthesiology, Associate Chief Medical Officer (Critical Care), Rush Shahid and Ann Carlson Khan Professor in Applied Health Sciences,
Medical College, Chicago, Illinois Department of Kinesiology and Community Health, University of
Arboviruses Affecting the Central Nervous System Illinois at Urbana-Champaign, Champaign, Illinois
Physical Activity
Joel A. Block, MD
The Willard L. Wood MD Professor and Director, Division of Pierre A. Buffet, MD, PhD
Rheumatology, Rush University Medical Center, Chicago, Illinois Research Unit Head, Erythrocyte Parasite Pathogenesis Research Team
Osteoarthritis INSERM–University Paris 6, CIMI–Paris Research Center, University
Pierre and Marie Curie; Associate Professor of Parasitology, Faculty of
Henk Blom, MD Medicine, University Pierre and Marie Curie, Pitié-Salpêtrière Hospital,
Laboratory of Clinical Biochemistry and Metabolism, Department of Paris, France
General Pediatrics, Adolescent Medicine and Neonatology, University Leishmaniasis
Medical Centre Freiburg, Head of Laboratory/Clinical Biochemical
Geneticist, Freiburg, Germany H. Franklin Bunn, MD
Homocystinuria and Hyperhomocysteinemia Professor of Medicine, Harvard Medical School; Physician, Brigham and
Women’s Hospital, Boston, Massachusetts
Olaf A. Bodamer, MD Approach to the Anemias
Medical Genetics, University of Miami Hospital, Miami, Florida
Approach to Inborn Errors of Metabolism David A. Bushinsky, MD
John J. Kuiper Distinguished Professor of Medicine, Chief, Nephrology
Division, University of Rochester School of Medicine; Associate Chair
for Academic Affairs in Medicine, University of Rochester Medical
Center, Rochester, New York
Nephrolithiasis
0008-v01-Co-AutoriUSA-XV-XXXVI.indd 17 24/05/17 14:43XVIII AUTORI
Vivian P. Bykerk, MD Naga P. Chalasani, MD
Associate Professor of Medicine, Weill Cornell Medical College; Associate David W. Crabb Professor and Director, Division of Gastroenterology and
Attending Physician, Hospital for Special Surgery, New York, New York Hepatology, Indiana University School of Medicine, Indianapolis,
Approach to the Patient with Rheumatic Disease Indiana
Alcoholic and Nonalcoholic Steatohepatitis
Peter A. Calabresi, MD
Professor of Neurology and Director of the Richard T. Johnson Division of Henry F. Chambers, MD
Neuroimmunology and Neuroinfectious Diseases, Johns Hopkins Professor of Medicine, University of California San Francisco School of
University; Director of the Multiple Sclerosis Center, Johns Hopkins Medicine; Director, Clinical Research Services, Clinical and
Hospital, Baltimore, Maryland Translational Sciences Institute, San Francisco, California
Multiple Sclerosis and Demyelinating Conditions of the Central Nervous System Staphylococcal Infections
David P. Calfee, MD, MS William P. Cheshire, Jr., MD
Associate Professor of Medicine and Healthcare Policy and Research, Weill Professor of Neurology, Mayo Clinic, Jacksonville, Florida
Cornell Medical College; Chief Hospital Epidemiologist, New York- Autonomic Disorders and Their Management
Presbyterian Hospital/Weill Cornell Medical Center, New York, New
York Ilseung Cho, MD, MS
Prevention and Control of Health Care–Associated Infections Assistant Professor of Medicine, Division of Gastroenterology, Department
of Medicine, New York University, New York, New York
Douglas Cameron, MD, MBA Human Microbiome
Professor of Ophthalmology and Visual Neurosciences, University of
Minnesota, Minneapolis, Minnesota Arun Chockalingam, PhD
Diseases of the Visual System Professor of Epidemiology and Global Health, Director, Office of Global
Health Education and Training; Dalla Lana Faculty of Public Health,
Michael Camilleri, MD University of Toronto, Toronto, Ontario, Canada
Atherton and Winifred W. Bean Professor, Professor of Medicine, Global Health
Pharmacology, and Physiology, College of Medicine, Mayo Clinic,
Consultant, Division of Gastroenterology and Hepatology, Mayo Clinic, David C. Christiani, MD
Rochester, Minnesota Professor of Medicine, Harvard Medical School; Physician, Pulmonary and
Disorders of Gastrointestinal Motility Critical Care, Massachusetts General Hospital; Elkan Blout Professor of
Environmental Genetics, Environmental Health, Harvard School of
Grant W. Cannon, MD Public Health, Boston, Massachusetts
Thomas E. and Rebecca D. Jeremy Presidential Endowed Chair for Physical and Chemical Injuries of the Lung
Arthritis Research, Associate Chief of Staff for Academic Affiliations,
George E. Wahlen VA Medical Center, Salt Lake City, Utah David H. Chu, MD, PhD
Immunosuppressing Drugs Including Corticosteroids Director, Contact Dermatitis, Division of Dermatology and Cutaneous
Surgery, Scripps Clinic Medical Group, La Jolla, California
Maria Domenica Cappellini, MD Structure and Function of the Skin
Professor of Internal Medicine, University of Milan, Fondazione IRCCS
Ca’ Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Theodore J. Cieslak, MD
Italy Pediatric Infectious Diseases, Clinical Professor of Pediatrics, University of
The Thalassemias Texas Health Science Center at San Antonio; Department of Pediatrics,
Fort Sam Houston, Texas
Blase A. Carabello, MD Bioterrorism
Professor of Medicine, Chairman, Department of Cardiology, Mount Sinai
Beth Israel Heart Institute, New York, New York Carolyn Clancy, MD
Valvular Heart Disease Interim Under Secretary for Health, Veterans Administration, Washington,
D.C.
Edgar M. Carvalho, MD Measuring Health and Health Care
Professor of Medicine and Clinical Immunology, Faculdade de Medicina da
Bahia, Universidade Federal da Bahia and Escola Bahiana de Medicina e David R. Clemmons, MD
Saúde Pública, Salvador, Bahia, Brazil Kenan Professor of Medicine, University of North Carolina School of
Schistosomiasis (Bilharziasis) Medicine; Attending Physician, Medicine, UNC Hospitals, Chapel Hill,
North Carolina
William H. Catherino, MD, PhD Approach to the Patient with Endocrine Disease
Professor and Research Head, Department of Obstetrics and Gynecology,
Uniformed Services University of the Health Sciences Division of David Cohen, MD
Reproductive Endocrinology and Infertility; Program in Reproductive Professor of Medicine, Division of Nephrology; Medical Director, Kidney
and Adult Endocrinology, Eunice Kennedy Shriver National Institute of and Pancreas Transplantation, Columbia University Medical Center,
Child Health and Human Development, National Institutes of Health, New York, New York
Bethesda, Maryland Treatment of Irreversible Renal Failure
Ovaries and Development; Reproductive Endocrinology and Infertility
Jeffrey Cohen, MD
Jane A. Cauley, DrPH Chief, Laboratory of Infectious Diseases, National Institute of Allergy and
Professor of Epidemiology, University of Pittsburgh Graduate School of Infectious Diseases, National Institutes of Health, Bethesda, Maryland
Public Health, Vice Chair of the Department of Epidemiology, Varicella-Zoster Virus (Chickenpox, Shingles)
Pittsburgh, Pennsylvania
Epidemiology of Aging: Implications of the Aging of Society
0008-v01-Co-AutoriUSA-XV-XXXVI.indd 18 24/05/17 14:43AUTORI XIX
Myron S. Cohen, MD Mary K. Crow, MD
Associate Vice Chancellor for Global Health, Director, UNC Institute for Joseph P. Routh Professor of Rheumatic Diseases in Medicine, Weill
Global Health and Infectious Diseases, Chief, Division of Infectious Cornell Medical College; Physician in Chief and Benjamin M. Rosen
Diseases, Yeargan-Bate Eminent Professor of Medicine, Microbiology, Chair in Immunology and Inflammation Research, Hospital for Special
and Immunology and Epidemiology, Chapel Hill, North Carolina Surgery, New York, New York
Approach to the Patient with a Sexually Transmitted Infection; Prevention of Hu- The Innate Immune Systems; Approach to the Patient with Rheumatic Disease;
man Immunodeficiency Virus Infection Systemic Lupus Erythematosus
Steven P. Cohen, MD John A. Crump, MB ChB, MD, DTM&H
Professor of Anesthesiology and Critical Care Medicine and Physical McKinlay Professor of Global Health, Centre for International Health,
Medicine and Rehabilitation, Johns Hopkins School of Medicine, University of Otago, Dunedin, New Zealand
Baltimore, Maryland, and Uniformed Services University of the Health Salmonella Infections (Including Enteric Fever)
Sciences, Bethesda, Maryland; Director, Pain Research, Walter Reed
National Military Medical Center, Bethesda, Maryland Mark R. Cullen, MD
Pain Professor of Medicine, Department of Medicine, Stanford University
School of Medicine, Stanford, California
Steven L. Cohn, MD Principles of Occupational and Environmental Medicine
Professor of Clinical Medicine, University of Miami Miller School of
Medicine; Medical Director, UHealth Preoperative Assessment Center; Charlotte Cunningham-Rundles, MD, PhD
Director, Medical Consultation Service, University of Miami Hospital, Professor of Medicine and Pediatrics, Icahn School of Medicine at Mount
Miami, Florida Sinai, New York, New York
Preoperative Evaluation Primary Immunodeficiency Diseases
Robert Colebunders, MD Inger K. Damon, MD, PhD
Emeritus Professor, Institute of Tropical Medicine, Antwerp, Belgium Director, Division of High Consequence Pathogens and Pathology, Centers
Immune Reconstitution Inflammatory Syndrome in HIV/AIDS for Disease Control and Prevention, Atlanta, Georgia
Smallpox, Monkeypox, and Other Poxvirus Infections
Joseph M. Connors, MD
Clinical Professor, University of British Columbia; Clinical Director, BC Troy E. Daniels, DDS, MS
Cancer Agency Centre for Lymphoid Cancer, Vancouver, British Professor Emeritus of Oral Pathology and Pathology, University of
Columbia, Canada California San Francisco, San Francisco, California
Hodgkin Lymphoma Diseases of the Mouth and Salivary Glands
Deborah J. Cook, MD, MSc Nancy E. Davidson, MD
Professor of Medicine, Clinical Epidemiology and Biostatistics, McMaster Hillman Professor of Oncology, University of Pittsburgh; Director,
University, Hamilton, Ontario, Canada University of Pittsburgh Cancer Institute and UPMC CancerCenter,
Approach to the Patient in a Critical Care Setting Pittsburgh, Pennsylvania
Breast Cancer and Benign Breast Disorders
Kenneth H. Cowan, MD, PhD
Director, Fred & Pamela Buffett Cancer Center; Director, The Eppley Lisa M. DeAngelis, MD
Institute for Research in Cancer and Allied Diseases; Professor of Chair, Department of Neurology, Memorial Sloan-Kettering Cancer
Medicine, University of Nebraska Medical Center, Omaha, Nebraska Center; Professor of Neurology, Weill Cornell Medical College, New
Cancer Biology and Genetics York, New York
Tumors of the Central Nervous System
Joseph Craft, MD
Paul B. Beeson Professor of Medicine and Immunobiology, Section Chief, Malcolm M. DeCamp, MD
Rheumatology, Program Director, Investigative Medicine, Department of Fowler McCormick Professor of Surgery, Feinberg School of Medicine,
Internal Medicine, Yale University School of Medicine, New Haven, Northwestern University; Chief, Division of Thoracic Surgery,
Connecticut Northwestern Memorial Hospital, Chicago, Illinois
The Adaptive Immune Systems Interventional and Surgical Approaches to Lung Disease
Jill Patricia Crandall, MD Carlos del Rio, MD
Professor of Clinical Medicine, Division of Endocrinology and Diabetes Hubert Professor and Chair and Professor of Medicine, Hubert
Research Center, Albert Einstein College of Medicine, Bronx, New York Department of Global Health, Rollins School of Public Health and
Diabetes Mellitus Department of Medicine, Emory University School of Medicine, Atlanta,
Georgia
Simon L. Croft, BSc, PhD Prevention of Human Immunodeficiency Virus Infection
Professor of Parasitology, Faculty of Infectious and Tropical Diseases,
London School of Hygiene and Tropical Medicine, London, United Patricia A. Deuster, PhD, MPH
Kingdom Professor and Director, Consortium for Health and Military Performance,
Leishmaniasis Department of Military and Emergency Medicine, Uniformed Services
University of the Health Sciences, Bethesda, Maryland
Kristina Crothers, MD Rhabdomyolysis
Associate Professor, Department of Medicine, Division of Pulmonary and
Critical Care, University of Washington School of Medicine, Seattle, Robert B. Diasio, MD
Washington William J. and Charles H. Mayo Professor, Molecular Pharmacology and
Pulmonary Manifestations of Human Immunodeficiency Virus and Acquired Im- Experimental Therapeutics and Oncology, Mayo Clinic, Rochester,
munodeficiency Syndrome Minnesota
Principles of Drug Therapy
0008-v01-Co-AutoriUSA-XV-XXXVI.indd 19 24/05/17 14:43XX AUTORI
David J. Diemert, MD Kathryn M. Edwards, MD
Associate Professor, Department of Microbiology, Immunology, and Sarah H. Sell and Cornelius Vanderbilt Chair in Pediatrics, Vanderbilt
Tropical Medicine, School of Medicine and Health Sciences, The George University School of Medicine; Director, Vanderbilt Vaccine Research
Washington University, Washington, D.C. Program, Monroe Carrell Jr. Children’s Hospital at Vanderbilt, Nashville,
Intestinal Nematode Infections; Tissue Nematode Infections Tennessee
Parainfluenza Viral Disease
Kathleen B. Digre, MD
Professor of Neurology, Ophthalmology, Director, Division of Headache N. Lawrence Edwards, MD
and Neuro-Ophthalmology, University of Utah, Salt Lake City, Utah Professor of Medicine, Vice Chairman, Department of Medicine, University
Headaches and Other Head Pain of Florida; Chief, Section of Rheumatology, Medical Service, Malcom
Randall Veterans Affairs Medical Center, Gainesville, Florida
James H. Doroshow, MD Crystal Deposition Diseases
Bethesda, Maryland
Approach to the Patient with Cancer; Malignant Tumors of Bone, Sarcomas, and Lawrence H. Einhorn, MD
Other Soft Tissue Neoplasms Distinguished Professor, Department of Medicine, Division of
Hematology/Oncology, Livestrong Foundation Professor of Oncology,
John M. Douglas, Jr., MD Indiana University School of Medicine, Indianapolis, Indiana
Executive Director, Tri-County Health Department, Greenwood Village, Testicular Cancer
Colorado
Papillomavirus Ronald J. Elin, MD, PhD
A.J. Miller Professor and Chairman, Department of Pathology and
Jeffrey M. Drazen, MD Laboratory Medicine, University of Louisville School of Medicine,
Distinguished Parker B. Francis Professor of Medicine, Harvard Medical Louisville, Kentucky
School; Senior Physician, Brigham and Women’s Hospital, Boston, Reference Intervals and Laboratory Values
Massachusetts
Asthma George M. Eliopoulos, MD
Professor of Medicine, Harvard Medical School; Physician, Division of
Stephen C. Dreskin, MD, PhD Infectious Diseases, Beth Israel Deaconess Medical Center, Boston,
Professor of Medicine and Immunology, Division of Allergy and Clinical Massachusetts
Immunology, Department of Medicine, University of Colorado Denver, Principles of Anti-Infective Therapy
School of Medicine, Aurora, Colorado
Urticaria and Angioedema Perry Elliott, MD
Professor in Inherited Cardiovascular Disease, Institute of Cardiovascular
W. Lawrence Drew, MD, PhD Science, University College London, London, United Kingdom
Professor Emeritus, Laboratory Medicine and Medicine, University of Diseases of the Myocardium and Endocardium
California San Francisco, San Francisco, California
Cytomegalovirus Jerrold J. Ellner, MD
Professor of Medicine, Boston University School of Medicine; Chief,
George L. Drusano, MD Section of Infectious Diseases, Boston Medical Center, Boston,
Professor and Director, Institute for Therapeutic Innovation, College of Massachusetts
Medicine, University of Florida, Lake Nona, Florida Tuberculosis
Antibacterial Chemotherapy
Dirk M. Elston, MD
Thomas D. DuBose, Jr., MD Director, Ackerman Academy of Dermatopathology, New York, New York
Emeritus Professor of Internal Medicine and Nephrology, Wake Forest Arthropods and Leeches
School of Medicine, Winston-Salem, North Carolina
Vascular Disorders of the Kidney Ezekiel J. Emanuel, MD, PhD
Vice Provost for Global Initiatives, Diane V.S. Levy and Robert M. Levy
F. Daniel Duffy, MD University Professor, Chair, Department of Medical Ethics and Health
Professor of Internal Medicine and Steve Landgarten Chair in Medical Policy, University of Pennsylvania, Philadelphia, Pennsylvania
Leadership, School of Community Medicine, University of Oklahoma Bioethics in the Practice of Medicine
College of Medicine, Tulsa, Oklahoma
Counseling for Behavior Change Joel D. Ernst, MD
Director, Division of Infectious Diseases and Immunology, Jeffrey Bergstein
Herbert L. DuPont, MD, MACP Professor of Medicine, Professor of Medicine, Pathology, and
Mary W. Kelsey Chair and Director, Center for Infectious Diseases, Microbiology, New York University School of Medicine; Attending
University of Texas School of Public Health; H. Irving Schweppe Chair Physician, New York University Langone Medical Center, New York,
of Internal Medicine and Vice Chairman, Department of Medicine, New York
Baylor College of Medicine; Chief of Internal Medicine, St. Luke’s Leprosy (Hansen Disease)
Hospital System, Houston, Texas
Approach to the Patient with Suspected Enteric Infection Gregory T. Everson, MD
Professor of Medicine, Director of Hepatology, University of Colorado
Madeleine Duvic, MD School of Medicine, Aurora, Colorado
Professor and Deputy Chairman, Department of Dermatology, The Hepatic Failure and Liver Transplantation
University of Texas MD Anderson Cancer Center, Houston, Texas
Urticaria, Drug Hypersensitivity Rashes, Nodules and Tumors, and Atrophic Amelia Evoli, MD
Diseases Associate Professor of Neurology, Catholic University, Agostino Gemelli
University Hospital, Rome, Italy
Disorders of Neuromuscular Transmission
0008-v01-Co-AutoriUSA-XV-XXXVI.indd 20 24/05/17 14:43AUTORI XXI
Douglas O. Faigel, MD Manuel A. Franco, MD, PhD
Professor of Medicine, Mayo Clinic, Chair, Division of Gastroenterology Director of Postgraduate Programs, School of Sciences, Pontificia
and Hepatology, Scottsdale, Arizona Universidad Javeriana, Bogota, Colombia
Neoplasms of the Small and Large Intestine Rotaviruses, Noroviruses, and Other Gastrointestinal Viruses
Matthew E. Falagas, MD, MSc, DSc David O. Freedman, MD
Director, Alfa Institute of Biomedical Sciences, Athens, Greece; Adjunct Professor of Medicine and Microbiology, University of Alabama at
Associate Professor of Medicine, Tufts University School of Medicine, Birmingham; Director, Gorgas Center for Geographic Medicine,
Boston, Massachusetts; Chief, Department of Medicine and Infectious Birmingham, Alabama
Diseases, Iaso General Hospital, Iaso Group, Athens, Greece Approach to the Patient before and after Travel
Pseudomonas and Related Gram-Negative Bacillary Infections
Martyn A. French, MD
Gary W. Falk, MD, MS Professor in Clinical Immunology, School of Pathology and Laboratory
Professor of Medicine, Division of Gastroenterology, University of Medicine, University of Western Australia, Perth, Australia
Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania Immune Reconstitution Inflammatory Syndrome in HIV/AIDS
Diseases of the Esophagus
Karen Freund, MD, MPH
Gene Feder, MBBS, MD Professor of Medicine, Associate Director, Tufts Clinical and Translational
Professor, Centre for Academic Primary Care, School of Social and Science Institute, Tufts University School of Medicine, Tufts Medical
Community Medicine, University of Bristol; General Practitioner, Helios Center, Boston, Massachusetts
Medical Centre, Bristol, United Kingdom Approach to Women’s Health
Intimate Partner Violence
Cem Gabay, MD
David J. Feller-Kopman, MD Professor of Medicine, Head, Division of Rheumatology, University
Director, Bronchoscopy and Interventional Pulmonology, Associate Hospitals of Geneva, Geneva, Switzerland
Professor of Medicine, The Johns Hopkins University, Baltimore, Biologic Agents
Maryland
Interventional and Surgical Approaches to Lung Disease Kenneth L. Gage, PhD
Chief, Entomology and Ecology Activity, Centers for Disease Control and
Gary S. Firestein, MD Prevention, Division of Vector-Borne Diseases, Bacterial Diseases
Dean and Associate Vice Chancellor of Translational Medicine, University Branch, Fort Collins, Colorado
of California San Diego School of Medicine, La Jolla, California Plague and Other Yersinia Infections
Mechanisms of Inflammation and Tissue Repair
John N. Galgiani, MD
Glenn I. Fishman, MD Professor of Medicine, Valley Fever Center for Excellence, University of
Director, Leon H. Charney Division of Cardiology, Vice-Chair for Arizona, Tucson, Arizona
Research, Department of Medicine, William Goldring Professor of Coccidioidomycosis
Medicine, New York University School of Medicine, New York, New
York Patrick G. Gallagher, MD
Principles of Electrophysiology Professor of Pediatrics, Pathology, and Genetics, Yale University School of
Medicine; Attending Physician, Yale–New Haven Hospital, New Haven,
Lee A. Fleisher, MD Connecticut
Robert D. Dripps Professor and Chair, Anesthesiology and Critical Care, Hemolytic Anemias: Red Blood Cell Membrane and Metabolic Defects
Professor of Medicine, University of Pennsylvania Perelman School of
Medicine, Philadelphia, Pennsylvania Leonard Ganz, MD
Overview of Anesthesia Director of Cardiac Electrophysiology, Heritage Valley Health System,
Beaver, Pennsylvania
Paul W. Flint, MD Electrocardiography
Professor and Chair, Otolaryngology, Head and Neck Surgery, Oregon
Health and Science University, Portland, Oregon Hasan Garan, MD
Throat Disorders Director, Cardiac Electrophysiology, Dickinson W. Richards, Jr. Professor
of Medicine, Columbia University Medical Center, New York, New York
Evan L. Fogel, MD, MSc Ventricular Arrhythmias
Professor of Clinical Medicine, Indiana University School of Medicine,
Indianapolis, Indiana Guadalupe Garcia-Tsao, MD
Diseases of the Gallbladder and Bile Ducts Professor of Medicine, Yale University School of Medicine; Chief, Digestive
Diseases, VA Connecticut Healthcare System, West Haven, Connecticut
Marsha D. Ford, MD Cirrhosis and Its Sequelae
Adjunct Professor of Emergency Medicine, School of Medicine, University
of North Carolina-Chapel Hill; Director, Carolinas Poison Center, William M. Geisler, MD, MPH
Carolinas HealthCare System, Charlotte, North Carolina Professor of Medicine, University of Alabama at Birmingham, Birmingham,
Acute Poisoning Alabama
Diseases Caused by Chlamydiae
Chris E. Forsmark, MD
Professor of Medicine, Chief, Division of Gastroenterology, Hepatology, Tony P. George, MD
and Nutrition, University of Florida, Gainesville, Florida Division of Brain and Therapeutics, Department of Psychiatry, University
Pancreatitis of Toronto; Schizophrenia Division, The Centre for Addiction and
Mental Health, Toronto, Ontario, Canada
Vance G. Fowler, Jr., MD, MHS Nicotine and Tobacco
Professor of Medicine, Duke University Medical Center, Durham, North
Carolina
Infective Endocarditis
0008-v01-Co-AutoriUSA-XV-XXXVI.indd 21 24/05/17 14:43XXII AUTORI
Lior Gepstein, MD, PhD Larry B. Goldstein, MD
Edna and Jonathan Sohnis Professor in Medicine and Physiology, Professor of Neurology, Director, Duke Stroke Center, Neurology, Duke
Rappaport Faculty of Medicine and Research Institute, Technion–Israel University; Staff Neurologist, Durham VA Medical Center, Durham,
Institute of Technology, Rambam Health Care Campus, Haifa, Israel North Carolina
Gene and Cell Therapy Approach to Cerebrovascular Diseases; Ischemic Cerebrovascular Disease
Susan I. Gerber, MD Lawrence T. Goodnough, MD
Team Lead, Respiratory Viruses/Picornaviruses, Division of Viral Professor of Pathology and Medicine, Stanford University; Director,
Diseases/Epidemiology Branch, National Center for Immunization and Transfusion Service, Stanford University Medical Center, Stanford,
Respiratory Diseases, Centers for Disease Control and Prevention, California
Atlanta, Georgia Transfusion Medicine
Coronaviruses
Eduardo H. Gotuzzo, MD
Dale N. Gerding, MD Professor of Medicine, Director, Alexander von Humboldt Tropical
Professor of Medicine, Loyola University Chicago Stritch School of Medicine, Medicine Institute, Universidad Peruana Cayetano Heredia; Chief
Research Physician, Edward Hines, Jr. VA Hospital, Hines, Illinois Physician, Department of Infectious, Tropical, and Dermatologic
Clostridial Infections Diseases, National Hospital Cayetano Heredia, Lima, Peru
Cholera and Other Vibrio Infections; Liver, Intestinal, and Lung Fluke Infections
Morie A. Gertz, MD
Consultant, Division of Hematology, Mayo Clinic, Rochester, Minnesota; Deborah Grady, MD, MPH
Roland Seidler, Jr. Professor of the Art of Medicine in Honor of Michael Professor of Medicine, University of California San Francisco, San
D. Brennan, MD, Professor of Medicine, Mayo Clinic, College of Francisco, California
Medicine, Rochester, Minnesota Menopause
Amyloidosis
Leslie C. Grammer, MD
Gordon D. Ginder, MD Professor of Medicine, Northwestern University Feinberg School of
Professor, Internal Medicine, Director, Massey Cancer Center, Virginia Medicine; Attending Physician, Northwestern Memorial Hospital,
Commonwealth University, Richmond, Virginia Chicago, Illinois
Microcytic and Hypochromic Anemias Drug Allergy
Jeffrey S. Ginsberg, MD F. Anthony Greco, MD
Professor of Medicine, McMaster University, Member of Thrombosis and Medical Director, Sarah Cannon Cancer Center, Nashville, Tennessee
Atherosclerosis Research Institute, St. Joseph’s Healthcare Hamilton, Cancer of Unknown Primary Origin
Hamilton, Ontario, Canada
Peripheral Venous Disease Harry B. Greenberg, MD
Professor, Departments of Medicine and Microbiology and Immunology,
Geoffrey S. Ginsburg, MD, PhD Stanford University School of Medicine, Stanford, California
Director, Duke Center for Applied Genomics and Precision Medicine; Rotaviruses, Noroviruses, and Other Gastrointestinal Viruses
Professor of Medicine, Pathology and Biomedical Engineering, Duke
University, Durham, North Carolina Steven A. Greenberg, MD
Applications of Molecular Technologies to Clinical Medicine Associate Professor of Neurology, Harvard Medical School; Associate
Neurologist, Brigham and Women’s Hospital, Boston, Massachusetts
Michael Glogauer, DDS, PhD Inflammatory Myopathies
Professor, Faculty of Dentistry, University of Toronto, Toronto, Ontario,
Canada Robert C. Griggs, MD
Disorders of Phagocyte Function Professor of Neurology, Medicine, Pediatrics, and Pathology and
Laboratory Medicine, University of Rochester School of Medicine and
John W. Gnann, Jr., MD Dentistry, Rochester, New York
Professor of Medicine, Department of Medicine, Division of Infectious Approach to the Patient with Neurologic Disease
Diseases, Medical University of South Carolina, Charleston, South
Carolina Lev M. Grinberg, MD, PhD
Mumps Professor, Chief, Department of Pathology, Ural Medical University;
Chief Researcher of the Ural Scientific Research Institute of
Matthew R. Golden, MD, MPH Phthisiopulmonology, Chief Pathologist of Ekaterinburg, Ekaterinburg,
Professor of Medicine, University of Washington, Director, HIV/STD Russia
Program, Public Health–Seattle & King County, Seattle, Washington Anthrax
Neisseria Gonorrhoeae Infections
Daniel Grossman, MD
Lee Goldman, MD Vice President for Research, Ibis Reproductive Health, Oakland, California;
Harold and Margaret Hatch Professor, Executive Vice President and Dean Assistant Clinical Professor, Bixby Center for Global Reproductive
of the Faculties of Health Sciences and Medicine, Chief Executive, Health, Department of Obstetrics, Gynecology and Reproductive
Columbia University Medical Center, Columbia University, New York, Sciences, University of California San Francisco, San Francisco,
New York California
Approach to Medicine, the Patient, and the Medical Profession: Medicine as a Contraception
Learned and Humane Profession; Approach to the Patient with Possible Cardio-
vascular Disease Lisa M. Guay-Woodford, MD
Hudson Professor of Pediatrics, The George Washington University;
Ellie J.C. Goldstein, MD Director, Center for Translational Science, Director, Clinical and
Clinical Professor of Medicine, David Geffen School of Medicine at Translational Institute at Children’s National, Children’s National Health
University of California Los Angeles, Los Angeles, California; Director, System, Washington, D.C.
R.M. Alden Research Laboratory, Santa Monica, California Hereditary Nephropathies and Developmental Abnormalities of the Urinary
Diseases Caused by Non–Spore-Forming Anaerobic Bacteria Tract
0008-v01-Co-AutoriUSA-XV-XXXVI.indd 22 24/05/17 14:43AUTORI XXIII
Richard L. Guerrant, MD Erik L. Hewlett, MD
Thomas H. Hunter Professor of International Medicine, Founding Director, Professor of Medicine and of Microbiology, Immunology, and Cancer
Center for Global Health, Division of Infectious Diseases and Biology, University of Virginia School of Medicine, University of Virginia
International Health, University of Virginia School of Medicine, Health System, Charlottesville, Virginia
University of Virginia Health Sciences Center, Charlottesville, Virginia Whooping Cough and Other Bordetella Infections
Cryptosporidiosis
Richard J. Hift, PhD, MMed
Roy M. Gulick, MD, MPH School of Clinical Medicine, University of KwaZulu-Natal, Durban, South
Gladys and Roland Harrison Professor of Medicine, Medicine/Infectious Africa
Diseases, Weill Cornell Medical College; Attending Physician, New York– The Porphyrias
Presbyterian Hospital, New York, New York
Antiretrovial Therapy of HIV/AIDS David R. Hill, MD, DTM&H
Professor of Medical Sciences, Director of Global Public Health, Frank H.
Klaus D. Hagspiel, MD Netter MD School of Medicine at Quinnipiac University, Hamden,
Professor of Radiology, Medicine, and Pediatrics, Chief, Noninvasive Connecticut
Cardiovascular Imaging, University of Virginia Health System, Giardiasis
Charlottesville, Virginia
Noninvasive Cardiac Imaging Nicholas S. Hill, MD
Professor of Medicine, Tufts University School of Medicine; Chief,
John D. Hainsworth, MD Division of Pulmonary, Critical Care, and Sleep Medicine, Tufts Medical
Chief Scientific Officer, Sarah Cannon Research Institute, Nashville, Center, Boston, Massachusetts
Tennessee Respiratory Monitoring in Critical Care
Cancer of Unknown Primary Origin
L. David Hillis, MD
Anders Hamsten, MD, PhD Professor and Chair, Department of Medicine, University of Texas Health
Professor of Cardiovascular Diseases, Center for Molecular Medicine and Science Center at San Antonio, San Antonio, Texas
Department of Cardiology, Karolinska University Hospital, Department Acute Coronary Syndrome: Unstable Angina and Non-ST Elevation Myocardial
of Medicine, Karolinska Institute, Stockholm, Sweden Infarction
Atherosclerosis, Thrombosis, and Vascular Biology
Jack Hirsh, CM, MD, DSc
Kenneth R. Hande, MD Professor Emeritus, McMaster University, Hamilton, Ontario, Canada
Professor of Medicine and Pharmacology, Vanderbilt/Ingram Cancer Antithrombotic Therapy
Center, Vanderbilt University School of Medicine, Nashville, Tennessee
Neuroendocrine Tumors and the Carcinoid Syndrome Steven M. Holland, MD
Chief, Laboratory of Clinical Infectious Diseases, National Institute of
H. Hunter Handsfield, MD Allergy and Infectious Diseases, National Institutes of Health, Bethesda,
Professor Emeritus of Medicine, University of Washington Center for AIDS Maryland
and STD, Seattle, Washington The Nontuberculous Mycobacteria
Neisseria Gonorrhoeae Infections
Steven M. Hollenberg, MD
Göran K. Hansson, MD, PhD Professor of Medicine, Cooper Medical School of Rowan University;
Professor of Cardiovascular Research, Center for Molecular Medicine at Director, Coronary Care Unit, Cooper University Hospital, Camden,
Karolinska University Hospital, Department of Medicine, Karolinska New Jersey
Institute, Stockholm, Sweden Cardiogenic Shock
Atherosclerosis, Thrombosis, and Vascular Biology
Edward W. Hook III, MD
Raymond C. Harris, MD Professor and Director, Division of Infectious Diseases, University of
Professor of Medicine, Ann and Roscoe R. Robinson Chair in Nephrology, Alabama at Birmingham, Birmingham, Alabama
Chief, Division of Nephrology, Vanderbilt University School of Granuloma Inguinale (Donovanosis); Syphilis; Nonsyphilitic Treponematoses
Medicine, Nashville, Tennessee
Diabetes and the Kidney David J. Hunter, MBBS, MPH, ScD
Vincent L. Gregory Professor of Cancer Prevention, Harvard School of
Stephen Crane Hauser, MD Public Health; Professor of Medicine, Harvard Medical School, Brigham
Associate Professor of Medicine, Internal Medicine, Division of and Women’s Hospital, Boston, Massachusetts
Gastroenterology and Hepatology, Mayo Clinic College of Medicine, The Epidemiology of Cancer
Rochester, Minnesota
Vascular Diseases of the Gastrointestinal Tract Khalid Hussain, MBChB, MD, MSc
Developmental Endocrinology Research Group, Clinical and Molecular
Frederick G. Hayden, MD Genetics Unit, Institute of Child Health, University College London,
Stuart S. Richardson Professor of Clinical Virology and Professor of Department of Paediatric Endocrinology, Great Ormond Street Hospital
Medicine, University of Virginia School of Medicine; Staff Physician, for Children, London, United Kingdom
University of Virginia Health System, Charlottesville, Virginia Hypoglycemia/Pancreatic Islet Cell Disorders
Influenza
Steven E. Hyman, MD
Douglas C. Heimburger, MD, MS Director, Stanley Center for Psychiatric Research, Broad Institute,
Professor of Medicine, Associate Director for Education and Training, Distinguished Service Professor of Stem Cell and Regenerative Biology,
Vanderbilt University School of Medicine, Vanderbilt Institute for Global Harvard University, Cambridge, Massachusetts
Health, Nashville, Tennessee Biology of Addiction
Nutrition’s Interface with Health and Disease
0008-v01-Co-AutoriUSA-XV-XXXVI.indd 23 24/05/17 14:43Puoi anche leggere
