Con il Paziente al centro Trasformazione Digitale del Farmaco - Ricerca, Produzione, Commercializzazione, Terapia
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#Pharma2020
Con il Paziente al centro
Trasformazione Digitale del Farmaco
Ricerca, Produzione, Commercializzazione, Terapia …
Milano, 7 febbraio 2019
Giuseppe Recchia, Vice Presidente Fondazione Smith Kline
#Pharma2020… 2007
#Pharma2020… Paziente e Tecnologia 2014
“E’ tempo di ascoltare i
#CuresNow veri esperti… i pazienti»
#Pharma2020… Paziente e Tecnologia 2019
COOK: But they’re things that we feel really great about, that we’ve been working on
for multiple years. On the healthcare, in particular, and sorta your wellbeing, this is an
area that I believe, if you zoom out into the future, and you look back, and you ask the
question, “What was Apple’s greatest contribution to mankind,” it will be about
health.
Because our business has always been about enriching people’s lives. And as we’ve
Tim Cook says that gotten into healthcare more and more through the Watch and through other things
improving people's that we’ve created with ResearchKit and CareKit and putting your medical records on
the iPhone, this is a huge deal.
health will be 'Apple’s And it’s something that is very important for people. We are democratizing it. We are
taking what has been with the institution and empowering the individual to manage
greatest contribution their health. And we’re just at the front end of this. But I do think, looking back, in the
future, you will answer that question, Apple’s most-important contribution to
to mankind' mankind has been in health.
21^ Century Cures Act 2017
Trasformazione Digitale dei Processi del Farmaco
• Digital Transformation è un insieme di cambiamenti di natura tecnologica,
persone con / senza malattia • Digital
culturale, organizzativa, sociale, associati con le applicazioni di tecnologia
digitale, in uno specifico aspetto della attività e della società umana
• Smartva
• Combinando in modo organico questi elementi, la Digital Transformation
R&D Produzione Marketing Sanità
oltre la semplice adozione di nuove tecnologie e permette di erogare servizi,
fornire beni, far vivere esperienze, trovare, elaborare e rendere accessibili
• Fast
grandi quantità di contenuti, creando nuove connessioni tra persone, luoghi e
cose, incentivando trasparenza, condivisione e inclusione di tutti i partecipanti.
tecnologie abilitanti • Change
Trasformazione Digitale dei Processi del Farmaco
persone con / senza malattia • Digital
• Smart
R&D Produzione Marketing Sanità
• Fast
tecnologie abilitanti • Change
Tecnologie Abilitanti 2019
Analizzare
Key Technology to Impact Healthcare in 2019, 4 Feb 2019
Predire
Interconnettere
Virtualizzare
Decentralizzare
Interagire da remoto
Elaborare in real time
Trasformazione Digitale dei Processi del Farmaco 30.1.2019
We want to help lead a Digital Revolution in our
industry
• We built a team of 1.500 experts across the
enterprise and are pursuing 12 major projects to
embed digital technologies and advanced data
analytics in our labs, factories and commercial
operations.
• For instance, a new system called Nerve Live uses
insights from hundreds of past drug development
clinical trials to help design and run more effective
trials today
Trasformazione Digitale dei Processi del Farmaco 30.1.2019
Ricerca & Sviluppo
1. Aggregate and Synthesize Information
2. Understand Mechanisms of Disease
3. Generate Data and Models Ricerca Scoperta Sviluppo
4. Repurpose Existing Drugs
5. Generate Novel Drug Candidates
6. Validate and Optimize Drug Candidates
Target Composto Prodotto
7. Design Drugs
8. Design Preclinical Experiments
9. Run Preclinical Experiments
10. Design Clinical Trials
11. Recruit for Clinical Trials
12. Optimize Clinical Trials
13. Publish Data Ricerca & Sviluppo
1. Aggregate and Synthesize Information
2. Understand Mechanisms of Disease Acellera
3. Generate Data and Models Ricerca Scoperta Sviluppo
Uses AI to: Predict protein-ligand binding.
4. Repurpose Existing Drugs Allows researchers to: Select better drug candidates,
5. Generate Novel Drug Candidates exclude toxic or reactive molecules, and improve
ADMET profiles.
6. Validate and Optimize Drug Candidates
7. Design Drugs
8. Design Preclinical Experiments
9. Run Preclinical Experiments
10. Design Clinical Trials
11. Recruit for Clinical Trials
12. Optimize Clinical Trials
13. Publish Data Modernizing Clinical Trials
Modernizing Clinical Trials
Digital Health technologies most likely
to improve clinical trial operations Modernizing Clinical Trials
Wearable Technology
Source: Trialtrove® April 2018 Modernizing Clinical Trials
Wearable Technology
Source: Trialtrove® April 2018 Modernizing Clinical Trials
Siteless Trials Modernizing Clinical Trials
AI in Clinical Trials
Processi Produttivi
Serializzazione
Continuous Manufacturing
Controllo Qualità Emerging technologies can make quality control (QC) faster and more efficient. What do pharma companies need to do to become QC leaders?
Marketing
Marketing
Engaging, Customer-Centric, Multi-Channel..
https://www.digitalpharmaconference.com/brochure-2
9:40
11:45
11:00
09:15
Patients
Integrate
Implement
Action &Your
Doctor
Business
Insights Engagement
Digital Channels
Change
& Engage Thought-Leaders
For Flawless
Seamlessly
& Influence HCPs With Discuss
Digital
& Transform The
360°Customer-
Your
Campaigns
Internal
Centric & Strategies
Most Appealing
Teams To& Embed
Strategies, Which
Engaging Engage
Strategies
Digital
Channels, &VR
In Sell
Pharma
Innovation
Webinars, & Digital
InCompelling
Your Organisation
Content
Marketing
For Today
Long-Term Sales & Relationships
Monetise Data & Customer Insights, Transform Cultures, Embed Digital
Innovation, Prove ROI, Empower The Sales-Force & Deliver Results – Get
Inspired By Today’s Digital Disruptors & Innovators AI e ISF
• SAN FRANCISCO - Artificial intelligence is a big buzzword in R&D right now,
but at Novartis, it's hard at work in the sales department, too.
Novartis puts AI on the job to help • Amid far more meetings with digital companies at the J.P. Morgan Healthcare
reps say the right things to the right
Conference this year, Novartis’ pharma CEO Paul Hudson said he expects
doctors, corner offices
2019 to be the “beginning of the tech disruption” for pharma, in everything
from marketing to supply chain.
Aside from ongoing and upcoming launches
for Novartis, the company's pharma • Obviously, Novartis is jumping right in, as part of CEO Vas Narasimhan's push
president Paul Hudson is excited about a
digital shakeup hitting the industry. to transform the entire company using digital tech. In the field, the
drugmaker has equipped salespeople with an AI service that suggests
doctors to visit and subjects to talk up during their meetings.
• The program's “virtual assistant” helps salespeople “plan better, move better
and make sure when they show up to see a healthcare professional, they are
talking about the things that the healthcare professional is absolutely
interested in,” Hudson said. Sanità
https://www.raiplay.it/video/2018/12/Report-630e3b5d-
0599-4376-8ae7-1bb7c05b5a30.html?tc=495668
• Digital Health
• Digital Healthcare Digital Health
Digital NHS
Smart Asthma
Trasformazione Digitale dei Processi del Farmaco 30.1.2019
Digital Therapeutics – Software come «principio attivo»… • Interventi Terapeutici • Software come Principio Attivo • Sviluppati attraverso RCTs • Autorizzati da enti regolatori • Sottoposti a valutazione HTA • Rimborsati da SSN / assicurazioni • Prescritti dal medico
Digital Therapeutics – mApps e Games come «eccipienti»…
Digital Therapeutics – Che cosa fanno?
Combinazione con il farmaco Alternativa al farmaco
Terapia di Combinazione Monoterapia
• Monitoraggio della aderenza alla terapia • Interventi cognitivo – comportamentali
• Raccomandazioni sul dosaggio del farmaco - Dipendenze (Novartis)
• Proposta di intervento medico - Insonnia
3
5
- Diabete (Roche) - Depressione
- Oncologia (AZ, Roche) - ADHD
- Malattie Respiratorie (GSK)
- Schizofrenia (Novartis)Digital Therapeutics – Come si sviluppano?
Analisi
Disegno
Studio
clinico
pilota
Sperimentazione clinica Introduzione nella
allargata (RCT) Pratica Medica
• Convalida SW medicale
• Marcatura CE • Aggiornamento Marcatura • Sorveglianza
• FDA Certification • Digital Therapeutic post market
Alice Ravizza e Giuseppe Recchia 2019Prepariamoci
Prepariamoci, è arrivato il nostro turno… 2019
Per sapere se andrà in questo modo….
@GGRecchia
@fsk_it
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