XVI NIBIT MEETING FINAL PROGRAMME - Milan, October 11-13, 2018 - Ospedale San Raffaele
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FINAL PROGRAMME
XVI NIBIT MEETING
Milan, October 11-13, 2018
San Raffaele Congress Centre, Milan
Under the auspices of
XV I N I B I T
Scientific Committee
Alberto Amadori, Padova Massimo Di Nicola, Milano
Matteo Bellone, Milano Pier Francesco Ferrucci, Milano
Marco Bregni, Busto Arsizio | VA Enrico Proietti, Roma
Luana Calabrò, Siena Vincenzo Russo, Milano
Mario Paolo Colombo, Milano
Local Scientific Organisers
Matteo Bellone, Milano
Vincenzo Russo, Milano
Faculty
Alberto Amadori Arianna Calcinotto
Università degli Studi di Padova, Institute of Oncology Research IOR,
Padova (Italy) Bellinzona (Switzerland)
Sebastian Amigorena Monica Casucci
Université Paris Descartes, IRCCS Ospedale San Raffaele,
Paris (France) Milano (Italy)
Matteo Bellone Mario Paolo Colombo
IRCCS Ospedale San Raffaele, IRCCS Istituto Nazionale dei Tumori,
Milano (Italy) Milano (Italy)
Andrea Botticelli Mark S. Cragg
Ospedale Sant’Andrea, University of Southampton,
Roma (Italy) Southampton (UK)
Marco Bregni Michele De Palma
Azienda Ospedaliera Ospedale di Circolo, École Polytechnique Fédérale
Busto Arsizio | VA (Italy) de Lausanne,
Lausanne (Switzerland)
Vincenzo Bronte
Università degli Studi di Verona, Anna Maria Di Giacomo
Verona (Italy) Azienda Ospedaliera Universitaria Senese,
Siena (Italy)
Luigi Buonaguro
Istituto Nazionale Tumori Massimo Di Nicola
IRCCS “Fondazione G. Pascale” IRCCS Istituto Nazionale dei Tumori,
Napoli (Italy) Milano (Italy)
Luana Calabrò Gianpietro Dotti
Azienda Ospedaliera Universitaria Senese, UNC School of Medicine,
Siena (Italy) Chapel Hill | NC (USA)
2
MEETING
Faculty
Soldano Ferrone Massimiliano Pagani
Massachusetts General Hospital, Università degli Studi di Milano,
Boston | MA (USA) Milano (Italy)
Pier Francesco Ferrucci Anna Pastò
Istituto Europeo di Oncologia IEO, Istituto Oncologico Veneto IOV,
Milano (Italy) Padova (Italy)
Wolf Herman Fridman Giuseppe Procopio
Université Paris Descartes, IRCCS Istituto Nazionale dei Tumori,
Paris (France) Milano (Italy)
Niels Halama Enrico Proietti
Universitätsklinikums Heidelberg, Istituto Superiore di Sanità,
Heidelberg (Germany) Roma (Italy)
Alexandre Harari Maria Pia Protti
CHUV centre hospitalier universitaire IRCCS Ospedale San Raffaele,
vaudois, Milano (Italy)
Lausanne (Switzerland)
Rahul Roychoudhuri
Guido Kroemer Babraham Institute,
Université Paris Descartes,
Cambridge (UK)
Paris (France)
Marco Ruella
Franco Locatelli
Penn Medicine Hospital of the University
IRCCS Ospedale Pediatrico Bambino Gesù,
of Pennsylvania,
Roma (Italy)
Pennsylvania | PA (USA)
Enrico Lugli
Istituto Clinico Humanitas,
Vincenzo Russo
Rozzano | MI (Italy) IRCCS Ospedale San Raffaele,
Milano (Italy)
Chiara Magnani
Università degli Studi di Milano Bicocca, Dario Sangiolo
Milano (Italy) Università degli Studi di Torino,
Torino (Italy)
Susanna Mandruzzato
Università degli Studi di Padova, Antonio Sica
Padova (Italy) Istituto Clinico Humanitas,
Rozzano | MI (Italy)
Massimo Massaia
Azienda Ospedaliera Citta’ Francesco Spagnolo
della Salute e della Scienza, IRCCS Ospedale San Martino,
Torino (Italy) Genova (Italy)
Federica Moschella Sjoerd van der Burg
Istituto Superiore di Sanità, Leiden University Medical Centre,
Roma (Italy) Leiden (The Netherlands)
Antonio Moschetta Laurence Zitvogel
Università degli Studi di Bari Aldo Moro, Université Paris-Sud,
Bari (Italy) Paris (France)
3
XV I N I B I T
SCIENTIFIC PROGRAMME
THURSDAY - OCTOBER 11
12.30 Light lunch and registration
14.00 Welcome addresses
Session 1 - Tumor Microenvironment I
Chairs: Massimo Di Nicola, Maria Pia Protti
14.15 Immune and tumor cell cooperations in shaping the tumor microenvironment
Wolf Herman Fridman (Paris, France)
14.40 In silico modeling of immunotherapy and stroma-targeting therapies
in human colorectal cancer
Niels Halama (Heidelberg, Germany)
15.05 Deep interrogation and profiling of tumor-infiltrating T lymphocytes
Alexandre Harari (Lausanne, Switzerland)
SELECTED ABSTRACTS
15.30 IL23 secreted by myeloid cells drives castration resistant prostate cancer
Arianna Calcinotto - Institute of Oncology Research IOR, (Bellinzona, Switzerland)
15.45 Breast cancer-adipocytes crosstalk as promoter of cancer progression
Tiziana Triulzi - Fondazione IRCCS Istituto Nazionale dei Tumori (Milano, Italy)
16.00 Coffee break
Session 2 - Tumor Microenvironment II
Chairs: Alberto Amadori, Arianna Calcinotto
16.20 Myelopoiesis in cancer: “Flipping” over monocytes into immune
regulatory cells
Vincenzo Bronte (Verona, Italy)
16.45 Single cell transcriptome analysis of human tumor-infiltrating lymphocytes
Massimiliano Pagani (Milano, Italy)
17.10 Chemotherapy, innate immunity and tumor metastasis
Michele De Palma (Lausanne, Switzerland)
SELECTED ABSTRACTS
17.35 Myeloid Derived Suppressor Cells-Mast Cells Cross-Talk Via CD40-CD40L
Mediates Tumor Specific Immunosuppression in Prostate Cancer
Elena Jachetti - Fondazione IRCCS Istituto Nazionale dei Tumori (Milano, Italy)
17.50 Role of anti-PD-1 antibody-Fc/FcR Interaction on Macrophages in inducing
hyperprogressive disease in non-small cell lung cancer
Michele Sommariva - Università degli Studi di Milano (Milano, Italy)
18.15 General Assembly of the NIBIT
19.30 POSTER SESSION
20.00 Welcome Wine & Cheese and Poster Viewing
4
MEETING
FRIDAY, OCTOBER 12
Session 3 - Adoptive Immunotherapy
Chairs: Marco Bregni, Monica Casucci
09.00 CAR-T cells in pediatric hematologic malignancies
Franco Locatelli (Roma, Italy)
09.25 Mechanisms of resistance to CAR-T cell therapy
Marco Ruella (Philadelphia, USA)
09.50 Chimeric antigen receptor for acute lymphoblastic leukemia:
challenges and opportunities
Chiara Magnani (Milano, Italy)
10.15 CAR-T cells in brain tumors
Gianpietro Dotti (Chapel Hill, USA)
SELECTED ABSTRACTS
10.40 Safety and efficacy of Anti-Leukemia CTL infusions for prevention/Treatment
of Leukemia relapse in high risk patients given Haploidentical HSCT
Daniela Montagna - Fondazione IRCCS Policlinico San Matteo (Pavia, Italy)
10.55 Monocyte-derived IL-1 and IL-6 are differentially required for cytokine release
syndrome and neurotoxicity by CAR-T cells
Margherita Norelli - Università Vita-Salute San Raffaele (Milano, Italy)
11.10 Generation of memory stem T cells specific for tumor antigens and resistant
to inhibitory signals by genome editing
Beatrice Claudia Cianciotti – IRCCS Ospedale San Raffaele (Milano, Italy)
11.25 Coffee break
Session 4 - Microbiota and Metabolism
Chairs: Matteo Bellone, Anna Pastò
11.40 Gut-liver axis in hepatocarcinoma
Antonio Moschetta (Bari, Italy)
12.05 Gut oncomicrobiome fingerprints in cancer
Laurence Zitvogel (Paris, France)
12.30 Metabolic reprogramming and myeloid cell heterogeneity in cancer
Antonio Sica (Milano, Italy)
SELECTED ABSTRACTS
12.55 Antioxidant metabolism regulates CD8+ T memory stem cell formation
and anti-tumor immunity
Karolina Pilipow - Istituto Clinico Humanitas (Rozzano - MI, Italy)
13.10 Harnessing the gut microbiome for personalized tumor prevention
and treatment
Luigi Nezi - Istituto Europeo di Oncologia IEO (Milano, Italy)
13.25 Lunch
5
XV I N I B I T
SCIENTIFIC PROGRAMME
Session 5 - Tumor and T cell Interactions
Chairs: Mario Paolo Colombo, Federica Moschella
14.25 Neoantigen landscape dynamics during human melanoma-T cell interactions
Sjoerd van der Burg (Leiden, The Netherlands)
14.50 Understanding agonism: rules and exceptions for TNF receptors
Mark S. Cragg (Southampton, UK)
15.15 Tumor-intrinsic PD1 expression: biological role and potential therapeutic relevance
Dario Sangiolo (Torino, Italy)
SELECTED ABSTRACTS
15.40 Identification of chemotherapy-induced self antigens suitable for DNA
vaccination in pancreatic cancer
Sara Bulfamante - Università degli Studi Torino (Torino, Italy)
15.55 Neoantigens released by Salmonella-infected tumor cells as
a novel vaccine platform
Alessia Melacarne - Istituto Clinico Humanitas (Rozzano - MI, Italy)
16.10 Analysis of potential immunological markers associated with the
PD-1 checkpoint inhibitor Nivolumab in non- small cell lung cancer patients
Selene Ottonello - Center of Excellence for Biomedical Research - CEBR (Genova, Italy)
16.25 Coffee break
16.40 Soldano Ferrone (Boston, USA)
introduces the Keynote Lecture
Keynote Lecture: Guido Kroemer (Paris, France)
Therapeutic manipulation of oncometabolism
and immunometabolism
17.40 POSTER SESSION
20.00 Social Dinner at Terrazza Aperol
SATURDAY, OCTOBER 13
Session 6 - Biology of T Cells in Cancer
Chairs: Susanna Mandruzzato, Enrico Proietti
09.00 Control of signal-driven transcriptional programmes in T cells
Rahul Roychoudhuri (Cambridge, UK)
09.25 Anti-tumor T cell immunity at single cell resolution
Enrico Lugli (Milano, Italy)
09.50 Epigenetic control of anti-tumor immune responses
Sebastian Amigorena (Paris, France)
10.15 Vγ9Vδ2 T cells activation by phosphoantigens released by antigen-presenting cells
Massimo Massaia (Torino, Italy)
6MEETING
SELECTED ABSTRACTS
10.40 Neoantigen landscape in low mutational load tumors in immunotherapy naive
and treated patients
Sara Bobisse - Ludwig Institute for Cancer Research (Lausanne, Switzerland)
15.55 Tetanus toxoid preconditioning and absence of temozolomide induce a strong
effector response associated to memory generation in patients with recurrent
GBM treated with dendritic cell (DC) - immunotherapy
Cristina Corbetta - Fondazione IRCCS Istituto Neurologico Carlo Besta (Milano, Italy)
11.10 Neutrophils driving unconventional T cells are essential for resistance
to sarcomas
Andrea Ponzetta – Istituto Clinico Humanitas (Rozzano – MI, Italy)
11.25 Coffee break
Session 7 - Clinical and Research Highlights Around NIBIT
Chairs: Luana Calabrò, Pier Francesco Ferrucci
11.40 Tyrosine Kinase Inhibitors and antitumor immune responses
Andrea Botticelli (Roma, Italy)
12.00 Progress in development of cancer vaccine for liver cancer:
the HEPAVAC clinical trial and beyond
Luigi Buonaguro (Napoli, Italy)
12.20 Immunotherapy in the treatment of urogenital cancer
Giuseppe Procopio (Milano, Italy)
12.40 Targeted therapies in the treatment of metastatic melanoma
Francesco Spagnolo (Genova, Italy)
13.00 The NIBIT Foundation Clinical Trials
Anna Maria Di Giacomo (Siena, Italy)
13.20 NIBIT Awards Nominations
13.35 Lunch
14.30 Adjourn
7Acknowledgments
Congress Venue
San Raffaele Congress Centre
Via Olgettina, 58
20132 Milano, IT
Organising Secretariat
Acheloís
Professional Congress Organiser
Via Olgettina 58 - Milano, IT
Phone: +39 02 2643 6227
e-mail: linda.isella@achelois.eu
ACHELOÍS - Professional Congress Organiser
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